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KMID : 0613820160260080970
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Journal of Life Science
2016 Volume.26 No. 8 p.970 ~ p.975
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The Suppression of Inflammatory Cytokines Induced by Propionibacterium acnes Using Bacteriocin Isolated from Lactobacillus plantarum K-1 BR
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Jeong Jin-Woong
Jung Yong-Hyun
Lee Jong-Sung
Yoon Seung-Won
Lee Seung-Youn
Lee Hong-Chan
Yoon Young Geol
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Abstract
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Acne vulgaris is a common chronic skin disorder that affects millions of people. The pathogenesis of acne has been known to be closely associated with the bacterium Propionibacterium acnes. Here we investigated the anti-acne activity of Lactobacillus plantarum K-1 BR by observing the expressions of pro- inflammatory cytokines, TNF-α, IFN-γ and IL-8, of human keratinocytes. When we applied heat-killed P. acnes to HaCaT cells, the inflammatory cytokines were induced by two- to four-fold compared to the normal control. When the bacteriocin, purified from L. plantarum K-1 BR, was pretreated to the HaCaT cells, the expression levels of TNF-α and IFN-γ stimulated by P. acnes significantly decreased to 25% and 30% of the induced levels, respectively. The IL-8 levels also significantly decreased with the concentration dependent manner of the bacteriocin. These results suggest that the bacteriocin from L. plantarum K-1 BR could reduce the expression levels of inflammatory cytokines and thus may relieve inflammations caused by acne.
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KEYWORD
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Anti-acne, bacteriocin, inflammatory cytokines, Lactobacillus plantarum K-1 BR, Propionibacterium acnes
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